Objective To evaluate the diagnostic value of linked color imaging （LCI） technology on Helicobacter pylori （HP）-related gastritis. Methods Forty patients who were diagnosed as chronic gastritis using blue laser imaging endoscopy in Shenzhen Hospital of Southern Medical University during November 2016 to June 2017 were enrolled in this study. The appearance of gastric mucosa was observed using conventional white light imaging and LCI. Biopsies were taken under white light imaging according to biopsy pathological diagnosis consensus， and the ones from abnormal reddening area were taken under LCI. 13C-urea breath test （13C-UBT） was performed in all 40 patients. The consistency between the two observation methods and final pathological diagnosis was evaluated using Kappa test， and the diagnostic consistency of the two methods was compared using Mc Nemar paired Chi-square test. Results The positive predictive value of white light imaging and LCI for prediction of HP infection was 54.5％ （6／11） and 81.5％ （22／27）， respectively. The consistency between white light imaging diagnosis and final pathological diagnosis was 0.475 （19／40）， Kappa=0.635； the consistency between LCI diagnosis and final pathological diagnosis was 0.875 （35／40）， Kappa=0.741. Mc Nemar paired Chi-square test showed that the consistency between the two methods had significant difference （P＜0.01）. 13C-UBT showed that 19 patients were positive and 21 negative. Among the 19 positive patients， 1 case was diagnosed as HP negative by pathology under LCI； and among the 21 negative patients， 4 cases were diagnosed as HP negative by pathology under LCI. The consistency between pathological diagnosis and 13C-UBT was good （Kappa=0.751）. The red-white boundary and diffuse redness of gastric mucosa were observed in 15 and 11 cases under LCI， respectively， while unobserved under white light imaging. The Wilcoxon signed ranks test showed that there was a significant difference between white light imaging and LCI on the appearance of gastric mucosa （Z=-4.455， P＜0.01）. Conclusion LCI is more useful for diagnosis of HP-related chronic gastritis than white light imaging.