Abstract:Objective To analyze the risk factors of delayed post-polypectomy bleeding (DPPB) of colonoscopy. Methods The data of 459 patients who underwent colonoscopic polypectomy between January 2014 and May 2017 were summarized, and the risk factors of DPPB were analyzed. Results Among the 459 patients, a total of 572 polyps were removed, and 27 patients with 42 polys occurred DPPB. Univariate analysis revealed that gender (male 85.2%), number of polyps removed (≥3 polyps, 59.3%), complicated with hyperlipidemia (29.6%), polyps’ diameter (≥10 mm, 66.7%), pathological type (adenoma, 95.2%), morphology (pedunculated, 81.0%), and excision method (endoscopic mucosal resection, 90.5%) were significantly correlated with DPPB (all P<0.05). Logistic regression analysis showed that gender, number of polyps removed, with hyperlipidemia, polyps’ size, and morphology were independent risk factors of DPPB (P<0.05). Conclusion: The risk factors of DPPB include male, complicated with hyperlipidemia, excision of more than 3 polyps, more than 10 mm in diameter, and pedunculated morphology.