Objective To evaluate the efficacy and safety of a novel lumen-apposing metal stent（LAMS） in endoscopic ultrasonography（EUS）-guided transgastric drainage of pancreatic fluid collections（PFC）. Methods A retrospective study of 46 patients was performed who underwent EUS-guided transgastric drainage of PFC with placement of LAMS from September 2015 to April 2017. Clinical data were reviewed and follow-up data were obtained by telephone and outpatient contact. Results A total of 49 LAMS were placed in 46 patients (2 LAMS were placed in 3 patient respectively for multiport access).The operation success rate was 95.9%（47/49）, complications occurred in 14 patients（31.8%), including 2 severe complications (delayed hemorrhage and peritonitis). Additional intervention was performed in 10 patients（22.7%）. The mean hospital stay was 6 days (1-40 days) and patients were followed for a mean time of 18.4 months (9-28 months). Treatment success was achieved in 40 patients（90.9%）. Stent removal was performed after a mean time of 59.4 days (20-142 days), and recurrence rate was 10%(4/40) during the follow-up period. Conclusion Drainage of PFC using LAMS with special design is effective and relatively safe.