ObjectiveTo investigate clinicopathological characteristics, diagnosis and treatment of multiple primary colorectal carcinoma (MPCC). MethodsFrom January 2008 to March 2017, 42 patients diagnosed with MPCC underwent surgery at Beijing Shijitan Hospital, Capital Medical University. Their clinicopathological features, diagnosis and treatment were analyzed. ResultsThese 42 MPCC patients accounted for 71% (42/592) colorectal cancer patients in the same period. There were 64 intestinal cancer lesions in 32 patients (762%) with synchronous carcinoma (SC), and 20 intestinal cancer lesions in 10 patients (238%) with metachronous carcinoma(MC), where the interval between the first and the recurrent was 18-105 months. The proportion of patients in the SC group with highly to moderately differentiated adenocarcinoma was significantly higher compared with that of the MC group (P<005), while the incidence of mucinous carcinoma was lower than that of the MC group(P<005). No significant differences were found with regard to tumor size, location, complications with adenoma, TNM stages, lymph nodes metastases or DNA mismatch repair between the SC group and the MC group(all P＞005). Among 42 patients undergoing radical operation, 6 received colonic metallic stent implantation as a bridge to elective resection in 10 patients with colonic obstruction. ConclusionMPCC, mainly two-lesion cancer, is most commonly found in sigmoid colon and rectum. Those with poorly differentiated cancer, mucinous carcinoma and those complicated with adenoma should be closely followed up with colonoscopy. Colonic metallic stent implantation as a bridge to elective resection may improve the detection rate of SC.