Objective To study the safety and efficacy of peroral endoscopic cardial constriction (PECC) for gastroesophageal reflux disease (GERD). Methods A total of 27 patients with GERD who visited the Affiliated Hospital of Inner Mongolia Medical University from August 2016 to December 2017 and met the inclusion criteria received PECC. The GERD health-related quality of life (GERD-HRQL) scores, GERD-questionnaires (GERD-Q) symptom scores, 24 h esophageal pH-resistance monitoring results and clinical efficacy before and after operation were compared. Results DeMeester score at 3 months (Z=-6.940, P=0.001) and 6 months (Z=-6.307, P =0.001) after treatment, GERD-HRQL score at 3 months (t=11.499, P =0.001) and 6 months (t=10.959, P =0.001) as well as GERD-Q symptom score at 3 months (t=30.647, P =0.001) and 6 months (t=27.217, P =0.001) after surgery significantly decreased, compared with those before. The curative rates were 81.5% (22/27) and 77.8% (21/27) at 3 months and 6 months after operation. Conclusions PECC, a new method for the treatment of GERD with good short-term effect, safety and feasibility，can be recommended for clinical application.