Objective：To explore the safety and efficacy of endoscopic submucosal dissection (ESD) for colorectal polyps larger than 2cm with thick and short stalks. Methods: From January 2015 to June 2017, patients with colorectal thick pedicle polyps undergoing endoscopic submucosal dissection were retrospectively analyzed. Clinical and pathological characteristics, clinical outcomes and complications were recorded and analyzed. Results: Fifty-five colorectal polyps with thick and short stalks diagnosed in 40 patients were completed removed by ESD. En bloc resection was achieved for all of the 55 lesions. The mean size of polyps was 2.8cm (range 2.0-4.0cm). The mean procedure duration was 15.9 (range 7-40). Twenty-eight patients experiencing pulsating bleeding (65%) were coagulated successfully endoscopically during the procedure. The blood volume ranged from 5ml to 100ml.There was no intraoperative or delayed perforation as well as delayed bleeding. The mean length of hospital stay was 1.3 day (range 1-4). There were 23 (57.5%) adenoma with low grade intraepithelial neoplasia, 15 (37.5%) carcinoma in situ, and two (5%) early carcinoma with superficial submucosal layer infiltration detected. R0 resection was obtained in all patients. The mean length of follow-up was 10.2 months (range 4-24). There was no recurrence or distant metastasis among 38 (95%) patients received colonoscopy during follow-up.