Clinically significant portal hypertension is the starting point of esophageal varices bleeding, ascites, hepatorenal syndrome, hepatic encephalopathy, etc.Understanding the presence or absence of portal hypertension and its severity in patients with liver disease is of great significance for assessing the condition, prognosis, selecting and developing treatment plan , evaluating the efficacy of treatment.Serological tests, imaging techniques including radionuclide imaging, ultrasound, CT, MRI, and endoscopy to evaluate portal hypertension from the mechanism of portal hypertension and the complications associated with portal hypertension.Have a certain diagnostic value, but can not quantify portal pressure。The non-invasive diagnostic model proposed in recent years has a good correlation with HVPG,Which provides a new idea for non-invasive portal hypertension detection and is expected to become an alternative technology for invasive HVPG.