Objective To investigate the therapeutic effects and safety of different stone extraction instruments in ERCP procedure, so as to provide clinical evidence for the instruments selection in ERCP bile duct stone extraction. Methods 178 cases of common bile duct sotone patients during January 2015 to August 2018 from Nanjing Jiangning hospital and Chizhou city people"s hospital were divided into three group: balloon catheter group, basket catheter group, and balloon combined with basket catheter group. One-time stone clearence rate, blood amylase level 24h after ERCP, and complication rate including bleeding, perforation and pancreatitis were retrospectively analysised in different group. Results Oe-time stone clearance rate of baloon group, basket group and basket combined with balloon group were 97.50%, 95.2% and 96.3%, respectively. There was no significant difference between the three groups (p>0.05). The blood amylase levels 24 hours after ERCP were 492.1±180.5u/ml, 231.3±289.3u/ml, 147.1 ±155.7u/ml, respectively (P>0.05). The incidence of hyperamylasemia after ERCP was 33.3%, 16.7% and 25.0%, respectively. The incidence of bleeding was 3.7%, 1.6% and 1.6%, respectively (P>0.05). The incidence of postoperative pancreatitis was 9.3%, 1.7% and 3.1%, respectively (P>0.05). There was no perforation in the three groups, but there was 1 case of basker stuck in the basket group. Conclusions Under the condition of fully papilla dilation, there were no significant difference between three groups, except for the higher blood amylase 24 hours after ERCP in balloon catheter group.