Objective To evaluate the effect of pre-cut-endoscopic mucosa resection of esophageal submucosal tumors. Methods 86 patients with esophageal submucosal tumors were enrolled from January 2016 to December 2018 who were detected by upper endoscopy and the tumor(maximum diameter <2.0cm)has been confirmed in muscularismucosaor submucosa by EUS.Thepatientswere randomly divided into two groups,45 patients were treated by pre-cut-endoscopic mucosal resection(observation group),and the other 41 patients were treated by conventionalendoscopic mucosal resection. The total resection of tumor was assessed after procedure and evaluate the healing of focus byupper endoscopy after 3 months .The clinical results includingprocedure time, all bloc resection rate,complication and recurrence rates were retrospectively evaluated.Results All the cases were successfully treated by endoscopicStreatment, the histopathological diagnoses of esophageal submucosal tumors included 79 liomyoma, 5 lipoma and 2 GISTs. In observation group,the all enbloc resection was achieved in 45 patients (100.0 %) with a mean operation time of (10.20 ± 2.42) min, and there were no such severe complications as bleeding and perforationhappening during and after operation.Incontrol group,theall bloc resection rate was 87.8% with a mean operation time of (10.46 ± 4.02) min, and 5Sunsuccessful operation were received additional ESD. The difference of all bloc resection rate between two groups have a statisticssignificance(P<0.05).Conclusion Pre-cut-endoscopic mucosal resection was an effective and safe therapy for esophageal submucosal tumors,and It has moreSobviousSadvantageSin all enblocresection,mean operation time and safety than conventionalendoscopic mucosal resection.