ObjectiveTo investigate the effect of traditional pancreatic duct stent and modified integrated pancreatic duct stent implantation in the treatment of pancreatic duct stenosis in patients with pancreatic duct stenosis. MethodsA total of 200 patients underwent endoscopic retrograde pancreatic ductography + pancreatic duct stent implantation in the Digestive Endoscopy Center of Shanghai Changhai Hospital from June 2018 to December 2018. There were 100 patients in the experimental group and 100 patientsin the control group. The one-time success rate ofoperation, the time of pancreatic duct stent implantation, the evaluation of medical satisfaction and cost-effectiveness were recorded and analyzed. SPSS20.0 is used for data processing and analysis. ResultsThere was no significant difference in education level, age and sex between the two groups (P> 0.05). However, there were significant differences in the one-time success rate of operation, the time of pancreatic duct stent implantation, medical satisfaction and cost-effectiveness (P< 0.05). ConclusionThe therapeutic effect and cost control of modified integrated pancreatic duct stent implantation in the treatment of pancreatic duct stenosis are significantly better than the traditional method, which is worth popularizing in clinic.