Objective To explore the efficiency of a new scoring system of gastric cancer screening for early gastric cancer in health examination population. Methods The risk score of gastric cancer was assessed based on the new scoring system in health examination population. A notice for further gastroscopy was sent to the medium-risk and high-risk people. Gastroscopy was performed on those who agreed to undergo the examination. Results From January to April 2019, a total of 5 357 people in health system visited the Physical Examination Center of Shanghai Songjiang Clinical Medical College of Nanjing Medical University for health examination. Seven hundred and forty people were classified as medium- and high-risk groups by the new screening system, 576 in medium-risk group, and 164 in high-risk group. Among them, 131 cases (17.70%) came for further gastroscopy, of whom 91 (69.47%) were in the medium-risk group and 40 (30.53%) in the high-risk group. After gastroscopy, 4 cases of gastric cancer and 1 case of esophageal cancer were detected, and both were early cancer. In the medium-risk group, 2 cases （2/91，2.20%） of early gastric cancer and 1 case （1/91，1.10%） of early esophageal cancer were found. In the high-risk group, 2 cases （2/40，5.00%）of early gastric cancer were found. The tumor detection rate of high-risk group (5.00%) was higher than that of medium-risk group (3.30%), but there was no significant difference (P>0.05). Conclusion Risk stratification with the new scoring system of gastric cancer screening can improve the detection rate of early gastric cancer.