改良内镜黏膜切除术治疗结肠扁平息肉的临床应用
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复旦大学附属中山医院厦门医院内镜中心

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厦门市医疗卫生指导性项目(3502z20199178)


The clinic application of modified endoscopic mucosal resection for flat colorectal polyps
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XIAMEN BRANCH,ZHONGSHAN HOSPITAL

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    摘要:

    目的 评价改良内镜黏膜切除术(M-EMR)治疗结肠扁平息肉疗效。方法 将276例297枚结肠扁平息肉患者随机分成两组:EMR组136例共152枚息肉,M-EMR组140例共145枚息肉。病灶黏膜下注射生理盐水后,EMR组一次性切除病灶,M-EMR组在病灶周边用圈套器头端切开周边黏膜后一次性切除病灶,回收全部标本送病理检查。比较术后两组并发症发生率,手术时间,完整切除率,术后复发率。结果 全部息肉一次性切除。EMR组1例迟发出血,1例穿孔,1例电凝综合征,并发症发生率2.0%(3/152);M-EMR组1例迟发出血,1例电凝综合征,并发症发生率1.4%(2/145)。EMR组息肉切除时间平均(5.6±2.0)min;M-EMR组息肉切除时间平均(5.7±2.1)min,2组无显著差异(p>0.05)。EMR组息肉完整切除率92.1%(140/152),M-EMR组息肉完整切除率100%(145/145),2组显著差异(p<0.05)。术后病理:管状腺瘤135例,绒毛状腺瘤40例,绒毛管状腺瘤57例,增生性息肉29例,炎性息肉34例。腺瘤伴高级别类瘤变8例,其中EMR组1例息肉残留,后行肠段切除,6个月后8例复查无复发。M-EMR组2例黏膜内癌,完整切除,6个月后复查无复发。EMR组12例术后残留,1例手术,11例APC处理后,1例6个月复发,复发率0.66%(1/152),M-EMR组无复发。结论 M-EMR组较EMR组治疗结肠扁平息肉更有效。

    Abstract:

    Objective To assess the clinical efficacy of modified endoscopic mucosal resection (M- EMR )treatment for flat colorectal polyps. Methods A total of 276 aged patients with flat colorectal polyps were divided into two groups randomly:EMR groups with 136 aged patients 152 lesions. M-EMR groups with 140 aged patients 145 lesions. After submucosal injection of physiological saline, EMR groups: enbloc resection were performed. M- EMR groups:cut open mucosa around the lesions before resection with snare pointed end. All resected specimens were retrieved for pathologic study. compare the rate of complication, the time of operation,the rate of enbloc resection and the rate of recurrence in the two groups.Results All polyps were removed completely. EMR groups: 1 delayed bleeding,1 perforation,1 postpolypectomy syndrome, the rate of complication was 2.0%(3/152). M-EMR groups : 1 delayed bleeding,1 postpolypectomy syndrome, the rate of complication was 1.4%(2/145) .The time of operation were(5.6±2.0)min in EMR groups, (5.7±2.1)min in M-EMR groups,there was no significant difference between two groups(p>0.05). The rate of enbloc resection was 92.1%(40/152)in EMR groups,The rate of enbloc resection was 100%(145/145)in M-EMR groups, there was statistic significance(p<0.05). Postoperative pathological examination showed 135 tubular adenomas, 40 villous adenomas, 57 tubular villous adenomas, 29 hyperplastic polyps, 34 inflammatory polys. 8 adenoma with high-grade intraepithelial neoplasia, 1 lesion was removed incompletely in EMR groups, resection of the involved intestinal segment was made,all showed no recurrence in 6 months. 2 mucosal carcinoma in M-EMR groups were removed completely , showed no recurrence in 6 months . 12 lesion was removed incompletely in EMR groups,1 operation,11 APC was made, showed 1 recurrence in 6 months ,the rate of recurrence was 0.66%(1/152),no recurrence in M-EMR groups. Conclusion M- EMR appears to be an efficacious procedure to treat flat colorectal polyps than EMR.

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林东,周平红.改良内镜黏膜切除术治疗结肠扁平息肉的临床应用[J].中华消化内镜杂志,2020,37(11):827-829.

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  • 收稿日期:2020-01-16
  • 最后修改日期:2020-06-12
  • 录用日期:2020-03-27
  • 在线发布日期: 2020-11-30
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