Objective To systematically evaluate the efficacy and safety of tissue adhesive combined with lauromacrogol (modified Sandwich method) for gastric varices. Methods Literature in the Cochrane Library, PubMed, EMbase, CNKI, VIP and Wanfang were searched by two independent researchers from the establishment of the databases to June 30, 2020, and qualified data from the eligible literature were extracted. Revman 5.3 was used to analyze outcomes including hemostatic efficiency, incidence of postoperative fever, chest and abdominal pain, ulcer, ectopic embolism and complications, and postoperative re-bleeding rate (Mantel-Haenszel method). Results A total of 8 randomized controlled trials including 898 patients were included in this meta-analysis. The results showed that compared with the classic Sandwich method, the modified version had a better hemostatic effect (P=0.01, OR=2.07, 95%CI: 1.17-3.68) and a lower incidence of postoperative ectopic embolism (P=0.001, OR=0.06, 95%CI: 0.01-0.34). There were no significant differences in the incidences of postoperative fever (P=0.58, OR=0.86, 95%CI: 0.52-1.44), chest and abdominal pain (P=0.83, OR=0.95, 95%CI: 0.58-1.56), local ulcer (P=0.31,OR=0.66, 95%CI: 0.30-1.47) , re-bleeding (P=0.14, OR=0.76, 95%CI: 0.53-1.09) or overall incidence of adverse reactions (P=0.24, OR=0.66, 95%CI: 0.33-1.32). Conclusion The modified Sandwich method of tissue adhesive combined with lauromacrogol is an effective and safe method in the treatment of gastric varices.