Biliary stones are common digestive disorders. Main treatment measures for biliary stones include surgery and endoscopic intervention, but treatment of certain difficult stones are still faced with challenges. Due to the safety and high efficiency, frequency-doubled double pulse laser lithotripsy is an effective method to treat difficult stones. The frequency-doubled double pulse neodymium-doped Yttrium Aluminum garnet laser has been approved by State Drug Administration for lithotripsy of biliary stones. However, there is no consensus on its indications, introduction methods and operating specifications. Therefore, on the basis of reference home and abroad, National Clinical Research Center for Digestive Diseases (Shanghai), Chinese Endoscopist Association and Chinese Society of Digestive Endoscopology organized domestic experts in fields of digestion, endoscopy and surgery to formulate this expert suggestion after full discussion, so as to provide guidance and reference for the standard conduction of laser lithotripsy for biliary stones in China.