Peutz‑Jeghers syndrome (PJS) is an autosomal dominant genetic disease, characterized by pigmentation of skin and mucosa, multiple hamartoma polyps of gastrointestinal tract and susceptibility to tumor. The small intestine is one of the predilection sites of polyps in PJS, which is usually complicated with intussusception, intestinal obstruction, bleeding or cancerization. With the rapid development of endoscopic technology, enteroscopy has become the key technology for the diagnosis and treatment of PJS. It plays an important role in the diagnosis and treatment of small bowel polys. In recent years, Chinese gastroenterologists have accumulated rich experience in endoscopic diagnosis and treatment of PJS with the advancement of clinical practice and acknowledgement of PJS. And it is necessary to launch a consensus on the diagnosis and treatment of PJS by enteroscopy so as to promote the application of enteroscopic technology in this field. This consensus included the epidemiology, genetic characteristics, clinical manifestations, diagnostic standard, endoscopic treatment, surgery, monitoring and follow-up of PJS based on evidence and experience of experts. This consensus may better guide the specialists and endoscopists to strengthen the standard diagnosis, treatment and management of PJS patients of full life circle in order to play a better role in the enteroscopic diagnosis and treatment for small bowel polyps in PJS patients.