From June 2017 to May 2021, 11 patients with insulinomas received endoscopic ultrasound‑guided fine needle injection (EUS‑FNI) at the Department of Gastroenterology, the Second Xiangya Hospital of Central South University. During a median follow‑up of 45 months (12‑60 months), symptoms of 6 patients were relieved with only 1 procedure of EUS‑FNI, 4 relieved with 2 procedures, and only 1 patient required more than 2 procedures. The results above preliminarily reveal that medium to long‑term efficacy of EUS‑FNI for insulinoma is good.