预测高龄胃早癌患者治疗方式选择的评分系统初探
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大连医科大学附属第一医院

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Scoring system for predicting treatment options of elderly patients with early gastric cancer: a preliminary study
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the First Affiliated Hospital of Dalian Medical University

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    【】 目的 通过寻找影响75岁以上高龄胃早癌患者生存预后的危险因素,以建立一个指导高龄胃早癌患者治疗方式选择的预测评分系统。 方法 收集2016年1月至2023年1月于大连医科大学附属第一医院内镜中心就诊并接受胃镜检查、内镜黏膜下剥离术或外科手术治疗的180例年龄≥75岁早期胃癌患者的临床资料,比较行ESD、外科手术及保守治疗的患者短期并发症的情况和长期生存预后结局,寻找影响患者预后的危险因素,以此建立一个预测评分系统。 结果 在ESD组、外科手术组、保守治疗组患者中,CCI(P=0.014,95%CI 1.196-4.864,HR 2.411)、PNI(P=0.011,95%CI 1.205-4.365,HR 2.294)、合并多原发癌(P=0.004,95%CI 1.401-5.585,HR 2.797)为影响生存预后的危险因素,将CCI>2、PNI≤43.275、合并多原发癌各分配1分,通过ROC曲线确定评分的最佳截断值为1.5(P<0.001,AUC=0.726)。以评分≤1和评分≥2分为低危组和高危组,比较两组下行不同治疗方式的高龄胃早癌患者的总生存期(OS),在低危组患者中,行ESD、外科手术相较于保守治疗总体生存期(OS)差异有统计学意义(P=0.003),而行ESD和外科手术差异无统计学意义(P=0.466);在高危组患者中,行ESD、外科手术、保守治疗总体生存期(OS)差异无统计学意义(P=0.152)。 结论 该评分系统中的指标(CCI、PNI、合并多原发癌)可以指导患者治疗方式的选择,其中评分≤1分时,建议行ESD或外科手术切除病灶;评分≥2分时,保守治疗可以减轻患者不必要的痛苦,是一个更好的选择。

    Abstract:

    【】 Objective? We aimed to create a scoring system to guide treatment options for gastric cancer patients aged≥75 years by searching for risk factors that affect the survival and prognosis. Methods? The clinical data of 180 patients with early gastric cancer aged ≥ 75 years who received gastroscopy, ESD or surgery at the Endoscopy Center of the First Affiliated Hospital of Dalian Medical University from January 2016 to January 2023 were collected.Compare the short-term complications and long-term survival outcomes of the three groups of patients under different treatment methods and find risk factors that affect patient prognosis, and create a predictive scoring system based on the scores of risk factors. Results? Among patients in the ESD group, surgery group, and conservative treatment group, CCI(P=0.014, 95%CI 1.196-4.864,HR 2.411), PNI(P=0.011, 95%CI 1.205-4.365, HR 2.294), combined multiple primary cancers(P=0.004, 95%CI 1.401-5.585,HR 2.797) are risk factors affecting survival prognosis.CCI>2, PNI≤43.275, and combined multiple primary cancers are each assigned 1 point. The optimal cutoff value for determining the score system through ROC curve is 1.5(P<0.001, AUC=0.726). The patients were divided into low-risk group and high-risk group based on score≤1 and score≥2, the overall survival(OS) of patients who received different treatments were compared between two groups. In the low-risk group, there was a statistically significant difference in overall survival(OS) between ESD, surgery and conservative treatment(P=0.003), but there was no statistically significant difference between ESD and surgery(P=0.466). In the high-risk group, there was no statistically significant difference in overall survival(OS) between ESD, surgery, and conservative treatment(P=0.152). The indicators in this scoring system(CCI, PNI, multiple primary cancers) can guide the choice of patients’ treatments. Conclusion? When the score is ≤1 point, ESD or surgery is recommended; when the score is ≥2 points, conservative treatment is a better choice which can relieve patients’ unnecessary pain.

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李睿博,宫爱霞.预测高龄胃早癌患者治疗方式选择的评分系统初探[J].中华消化内镜杂志,,().

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  • 收稿日期:2023-12-20
  • 最后修改日期:2024-02-05
  • 录用日期:2024-03-11
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