ObjectiveTo investigate the clinical application of preliminarilyriskassessment of upper gastrointestinal bleeding in elderly patients taking enteric-coated aspirin. MethodsAnalyzing the clinical data of patients taking enteric-coated aspirin and undertakingmagnetically controlled capsule endoscopy (MCCE) between January,2018 and December, 2020, at the digestive department of Beijing chaoyang and Beijing Anzhen hospital, CapitalMedical University. Patients were divided into low-risk group (score ≤ 3) and moderate/high risk group (score ＞3) according to the preliminarilyriskassessment of upper gastrointestinal bleeding in elderly patients taking enteric-coated aspirin. Results66 patients (age 60-81years,male/female 45/21)were entered. The values of low-risk and moderate/high risk groups were as follow: the rates of upper gastrointestinal bleeding were 7.6% and 53.3%(P < 0.001),gastric ulcer 5.9%and 26.7%(P < 0.001),duodenal ulcer 2.0% and 18.8%(P < 0.001)；mediangastricLanza score 2.0 and 2.0(P = 0.621),median duodenal mucosal injury 1.0 and 1.0(P = 0.936). Receiver operator characteristic curve showed that the area under the curve of preliminarily risk assessment of upper gastrointestinal bleeding in elderly patients taking enteric-coated aspirin for predicting upper gastrointestinal bleeding was 0.855(P <0.001).Conclusionpreliminarily risk assessment of upper gastrointestinal bleeding in elderly patients taking enteric-coated aspirin can be used to predict risk of upper gastrointestinal bleeding, but the scoring rules need to be further improved. Moderate and high-risk patients should undertake MCCEtomonitor aspirin related upper gastrointestinal mucosal injury.