Small bowel capsule endoscopy has been widely used in clinical practice, which has become the first-line method for diagnosing small bowel diseases. In order to standardize the examination procedure, clarify the indications and contraindications of small bowel capsule endoscopy, with combination of clinical practice in China, National Clinical Research Center for Digestive Diseases (Shanghai), National Digestive Endoscopy Improvement System, Capsule Endoscopy Collaborative Group of Chinese Society of Digestive Endoscopy and Capsule Endoscopy Group of Digestive Endoscopy Branch of Shanghai Medical Association formulated this guideline based on existent evidence using the grading of recommendation assessment, development, and evaluation (GRADE) approach and following the reporting standaard of international guidelines. This guideline will provide guidance and decision-making basis for Chinese physicians.