The esophagogastroduodenoscope (EGD) is an effective tool for diagnosing upper gastrointestinal tumors, precancerous lesions and critical emergency diseases. Artificial intelligence (AI) technology plays a significant role in the quality control and auxiliary diagnosis of EGD. However, currently there is no consensus on the application of EGD AI system at home or abroad. In 2023, organizing discussions among nationwide authoritative experts in the field, and combining the latest evidence-based medical evidence at home and abroad, Digestive Endoscopology Branch of Chinese Medical Association has formulated an expert consensus on the clinical application of EGD AI system, in order to provide clinicians with a reasonable decision-making basis when using EGD AI. This consensus consists of 13 recommendations including blind spot monitoring under gastroscopy, esophageal abnormal lesion identification, prediction of esophageal cancer infiltration depth, grading of esophageal gastric varices, identification of gastric abnormal lesions, and clinical application requirements for EGD AI system.