内镜下≤20 mm直肠神经内分泌肿瘤非治愈性切除风险预测模型的建立与验证
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作者单位:

1.苏州市第九人民医院消化内科;2.苏州市第九人民医院 消化内科;3.苏州第九人民医院 消化内科;4.苏州大学附属第一医院 消化内科

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苏州市第九人民医院院级青年科研基金项目(YK202506)


Establishment and validation of a risk model for non‑curative resection of rectal neuroendocrine tumors ≤20 mm under endoscopy
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Affiliation:

Suzhou Ninth People''s Hospital

Fund Project:

Suzhou Ninth People''s Hospital?Level Youth Scientific Research Fund Project (YK202506)

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    摘要:

    目的 建立≤20 mm直肠神经内分泌肿瘤(rectal neuroendocrine tumors, R⁃NETs)的非治愈性切除风险预测模型并验证其效能。方法 回顾分析苏州大学附属第一医院、苏州市第九人民医院2013年1月至2023年12月收治的R⁃NETs患者数据,分析临床资料、镜下表现、病理结果特点,通过独立样本t检验,卡方检验进行单因素分析。二元logistic回归中向前法筛选变量,建立≤20 mm R⁃NETs的非治愈性切除风险预测模型并绘制列线图。通过受试者工作特征(receiver operating characteristic,ROC)曲线评估模型检验效能,校准曲线评估预测概率和观测概率一致性是否良好,决策曲线评估模型是否具有临床净收益。结果 纳入213例患者,年龄为(50.53±11.42)岁,102例(47.9%)为男性。病变距齿状线(7.11±2.79)cm。肿瘤长径为(8.24±3.75)mm。单因素分析得出,与治愈性切除病例相比,非治愈性切除病例更多呈现肿瘤表面凹陷、有更高的肿瘤G分期、更高的Ki⁃67指数和更高的嗜铬粒蛋白A (chromograninA,CgA)阳性率(P<0.05)。通过多因素logistic回归中向前筛选变量法,筛选出以Ki⁃67指数(P=0.014,OR=1.214,95%CI:1.039~1.417)、表面凹陷(P=0.027,OR=2.348,95%CI:1.100~5.013)、CgA阳性(P<0.001,OR=5.399,95%CI:2.764~10.544)为参数的模型,并建立列线图。模型ROC曲线下面积为0.766(95%CI: 0.696~0.837),临床决策曲线分析证实模型有良好的临床净收益。校准曲线显示模型预测概率和观测概率一致性良好。结论 本研究建立以表面凹陷、Ki⁃67指数、CgA阳性为参数的≤20 mm R⁃NETs的非治愈性切除风险预测模型。该模型具有较好的预测效能,可作为临床内镜医师的参考依据。

    Abstract:

    Objective To establish and validate a predictive model for non-curative resection of rectal neuroendocrine tumors (R-NETs) ≤20 mm. Methods Data from patients with R-NETs treated at the First Affiliated Hospital of Soochow University and the Suzhou Ninth People''s Hospital from January 2013 to December 2023 were retrospectively analyzed. Clinical data, endoscopic findings, and pathological characteristics were analyzed. Univariate analysis was performed using independent sample t-tests and Chi-square tests. Variables were screened using the forward stepwise binary logistic regression to establish a risk prediction model for non-curative resection of R-NETs ≤20 mm, with subsequent construction of a nomogram. The performance of the model was evaluated using the receiver operating characteristic (ROC) curve. The consistency between predicted and observed probabilities was assessed using calibration curves, and the clinical net benefit of the model was evaluated using decision curve analysis. Results A total of 213 patients were included, with age of 50.53±11.42 years, and 102 (47.9%) were male. The distance of the lesion from the dentate line was 7.11±2.79 cm, and the tumor long diameter was 8.24±3.75 mm. Compared to curative resection cases, non-curative resection cases were more likely to exhibit tumor surface depression, higher tumor G-stage, higher Ki-67 index and higher chromograninA (CgA) positivity rate (P<0.05). Through forward variable selection in binary logistic regression, a model was established with Ki-67 index (P=0.014, OR=1.214, 95%CI: 1.039-1.417), surface depression (P=0.027, OR=2.348, 95%CI: 1.100-5.013), and CgA positivity (P<0.001, OR=5.399, 95%CI: 2.764-10.544) as parameters, with a corresponding nomogram. The area under the ROC curve of the model was 0.766 (95%CI: 0.696-0.837), and clinical decision curve analysis confirmed its good clinical net benefit. The calibration curve showed good consistency between predicted and observed probabilities. Conclusion This study establishes a risk prediction model for non-curative resection of R-NETs ≤20 mm based on surface depression, Ki-67 index, and CgA positivity. The model demonstrates strong predictive performance and offers valuable guidance for clinical endoscopists.

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杨菱霞,顾毅杰,凌鑫,等.内镜下≤20 mm直肠神经内分泌肿瘤非治愈性切除风险预测模型的建立与验证[J].中华消化内镜杂志,2025,42(4):302-306.

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  • 收稿日期:2024-05-13
  • 最后修改日期:2025-04-05
  • 录用日期:2024-09-09
  • 在线发布日期: 2025-04-09
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