Endoscopic duodenal-jejunal bypass liner implantation (EDJBLI) is a minimally invasive weight-loss procedure with similar mechanisms to bariatric metabolic surgery. It achieves weight control by limiting nutrient absorption and regulating gastrointestinal hormone secretion. Given the lack of expert consensus or guidelines for this technique both domestically and internationally, this expert opinion was formulated based on current clinical evidence. It systematically outlines the indications, contraindications, operating specifications and key points for the prevention and treatment of complications associated with this procedure, to provide guidance and clinical practice references for the standardized implementation of this treatment in China.