ObjectiveTo evaluate the safety and efficacy of rubber band and clip facilitated endoscopic submucosal dissection (RACESD) for colorectal neoplasms. MethodsA retrospective cohort study was performed. Clinical data of 115 patients with colorectal neoplasm receiving ESD from September 2018 to August 2019 were retrospectively analyzed. Thirtyfour patients received RACESD treatment (RACESD group) and 81 received conventional ESD treatment (conventional ESD group). The procedure time, the dissected area per minute during ESD, en bloc resection rate, complete resection rate, curative resection rate, complication occurence and recurrence rate were compared between the two groups. ResultsThe median specimen area of RACESD group was 632 (753) cm2， and the median procedure time was 400 (550) min. The mean dissected area per minute was 014 (020) cm2/min. While in conventional ESD group, the median specimen area was 471 (502) cm2, the median procedure time was 500 (500) min and the mean dissected area per minute was 009 (007) cm2/min. The median specimen area of RACESD group was slightly larger and the median procedure time was slightly shorter than those of conventional ESD group, but neither was significantly different（both P＞0.05）. The median dissected area per minute of RACESD group was significantly larger than that of the conventional ESD group (P=0008). The en bloc resection rate, complete resection rate and curative resection rate of RACESD group were 1000% （34/34）, 1000% （34/34） and 971% （33/34）, while those of the conventional ESD group were 100.0%（81/81）, 96.3%（78/81） and 91.4%（74/81）， respectively. There was no ESDrelated complication in either group. After 100±55 months of followup, there was no local recurrence in both groups. ConclusionRACESD may increase resection efficacy with safety.